Adding Nebulized Salbutamol to Intravenous Atropine and Oxygen in OP Poisoning

• Status: Completed
• Trial end date: 2015-12-01
• Target enrollment: 0
• Participant gender: All

Summary

We hypothesize that salbutamol will speed removal of alveolar fluid compared to atropine alone in OP poisoned patients. We propose to compare the effect of two stat doses of nebulized salbutamol (2.5 mg; 5.0 mg), with nebulized saline placebo, in symptomatic patients receiving standard resuscitation with atropine, oxygen, and fluids after poisoning with OP pesticides. 25 patients will be randomised to each arm (total 75 patients). Primary outcome will be oxygen saturation's over the following 60 min during resuscitation. Secondary outcomes will include atropine dose administered, speed to stabilization, aspiration or pneumonia, intubation, tachydysrhythmias, and mortality. A positive outcome will result in design of a large definitive phase III study.

• Phase: Phase 3
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Sylhet M.A.G.Osmani Medical College
• Collaborator: University of Edinburgh
• Treatments: Albuterol; Atropine; Muscarinic Antagonists; Pharmaceutical Solutions; Pralidoxime

Criteria

Inclusion Criteria:

• age 12 yrs or older

• clinical features of OP poisoning

• requiring oxygen and atropine and give consent

Exclusion Criteria:

• age 11 yrs or younger

• no requirement for atropine