Adding Prednisolone During Ovulation Induction With CC in Lean Women With CC Resistant PCOS

• Status: Unknown status
• Trial end date: 2019-01-01
• Target enrollment: 0
• Participant gender: Female

Summary

The purpose of this study is to evaluate the effect of concomitant administration of prednisolone during use of clomiphene citrate (CC) for induction of ovulation in infertile lean women having CC resistant polycystic ovarian syndrome (PCOS).

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Mahmoud Thabet; Mohamed Sayed Abdelhafez
• Treatments: Citric Acid; Clomiphene; Enclomiphene; Folic Acid; Methylprednisolone; Methylprednisolone acetate; Methylprednisolone Hemisuccinate; Prednisolone; Prednisolone acetate; Prednisolone hemisuccinate; Prednisolone phosphate; Sodium Citrate; Vitamin B Complex; Zuclomiphene

Criteria

Inclusion Criteria:

• Infertile lean women with PCOS as defined by the Rotterdam criteria.

• CC resistance (defined as failure of ovulation after receiving 150 mg/day of CC for 5 consecutive days per cycle, for at least 3 consecutive cycles).

Exclusion Criteria:

• Age < 20 or > 35 years.

• Body mass index (BMI) < 18.5 kg/m2 or > 25 kg/m2.

• Presence of any infertility factor other than anovulatory PCOS.

• Previous history of ovarian surgery or surgical removal of one ovary.

• Previous exposure to cytotoxic drugs or pelvic irradiation.

• Oral hypoglycemic or hormonal therapy either currently or in the preceding 3 months.

• Metabolic or hormonal abnormalities