Adding a Short Burst of Corticosteroid to the Conventional Treatment of H1 Antihistamines in Emergency Department.

• Status: Completed
• Trial end date: 2019-10-31
• Target enrollment: 0
• Participant gender: All

Summary

A randomized, double-blinded, controlled trial of adding a short burst of corticosteroid to the conventional treatment of H1 antihistamines

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Chulalongkorn University
• Treatments: BB 1101; Dexamethasone; Dexamethasone acetate; Histamine Antagonists; Histamine H1 Antagonists; Methylprednisolone; Methylprednisolone acetate; Methylprednisolone Hemisuccinate; Prednisolone; Prednisolone acetate; Prednisolone hemisuccinate; Prednisolone phosphate

Criteria

Inclusion Criteria:

• Patients visit emergency room at King chulalongkorn memorial hospital (KCMH) age between 18-50 years who meet the following criteria of acute urticarial such as

1. eruption of wheals, central swelling of various sizes, with or without surrounding erythema; with or without angioedema

2. pruritus or occasional burning sensation

3. skin returning to normal appearance, usually within 1-24 hours

Exclusion Criteria:

1. patients who have urticarial for more than 48 hours

2. have severe underlying disease such as heart disease, kidney disease, liver disease

3. pregnancy

4. history of chlorpheniramine maleate, steroid, antihistamines allergy

5. history of antihistamine or steroid uses within 48 hours before ED visit

6. diabetes mellitus

7. suspected of more severe disease or severe allergic reaction

8. patients who don't have pruritus

9. patients who have history of chronic urticaria