Addition of Modulators of Homocysteine to Adalimumab Therapy in the Treatment of Moderate to Severe Plaque Psoriasis
Status:
Terminated
Trial end date:
2014-05-01
Target enrollment:
Participant gender:
Summary
Vitamins modulating homocysteine affect both TNF-alpha, vascular endothelial growth factor,
and theoretically enhance the anti-inflammatory version of NOS thus hopefully increasing the
efficacy and reducing the chance of some toxicities of adalimumab as determined by blood
testing and EKGs.
Phase:
Phase 1/Phase 2
Details
Lead Sponsor:
Wayne State University
Collaborator:
Abbott
Treatments:
Adalimumab Folic Acid Hydroxocobalamin Pyridoxal Pyridoxine Vitamin B 12 Vitamin B 6 Vitamin B Complex Vitamins