Additional Anti-emetic Effect of Ramosetron Prophylaxis After Total Knee Arthroplasty

• Status: Completed
• Trial end date: 2010-03-01
• Target enrollment: 0
• Participant gender: All

Summary

The purposes of this study are to document the antiemetic efficacy of multimodal antiemetic protocol in patient after Total Knee Arthroplasty using regional anesthesia, midazolam & propofol, hydration & oxygen supplement, preemptive & multimodal contemporary pain management and to determine whether Ramosetron prophylaxis would provide additional antiemetic effect on this protocol. We hypothesized that the incidence of Postoperative nausea and vomiting during multimodal antiemetic protocol would be lower than Apfel's expected postoperative nausea and vomiting incidence. It was also hypothesized that Ramosetron prophylaxis would provide additional antiemetic effect.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Seoul National University Hospital
• Treatments: Antiemetics; Emetics; Ramosetron

Criteria

Inclusion Criteria:

• Diagnosis of primary osteoarthritis, knee

• Scheduled for elective total knee arthroplasty

• Signed written informed consent

Exclusion Criteria:

• Refusing participate

• Contraindication to regional anesthesia

• Severe impairment of bowel motility

• administration of other antiemetics within 24hours before surgery

• systemic steroid within 24hours before surgery

• history of cardiovascular & respiratory disease

• renal & hepatic failure