Additional Anti-emetic Effect of Ramosetron Prophylaxis After Total Knee Arthroplasty
Status:
Completed
Trial end date:
2010-03-01
Target enrollment:
Participant gender:
Summary
The purposes of this study are to document the antiemetic efficacy of multimodal antiemetic
protocol in patient after Total Knee Arthroplasty using regional anesthesia, midazolam &
propofol, hydration & oxygen supplement, preemptive & multimodal contemporary pain management
and to determine whether Ramosetron prophylaxis would provide additional antiemetic effect on
this protocol. We hypothesized that the incidence of Postoperative nausea and vomiting during
multimodal antiemetic protocol would be lower than Apfel's expected postoperative nausea and
vomiting incidence. It was also hypothesized that Ramosetron prophylaxis would provide
additional antiemetic effect.