Additional Screening With Sensitives RDTs and Malaria
Status:
Recruiting
Trial end date:
2021-12-01
Target enrollment:
Participant gender:
Summary
National malaria control strategies in pregnant women relies primarily on effective case
management along with the use of long lasting insecticide-treated nets (LLINs)throughout
pregnancy and intermittent preventive treatment with sulfadoxine-pyrimethamine (IPTp-SP) in
the second and third trimesters in malaria-endemic regions in sub-Saharan Africa (SSA). For
the latter, 3 or more doses are recommended by the national malaria control program (NMCP)
but available data suggests that only 19% of eligible women received this in 2016 despite
observed high attendance to antenatal clinic (ANC). Adherence to IPTp may be affected by
perceptions, acceptability and contextual factors that need to be understood and therefore
improve the effectiveness of this health interventions. In addition, all malaria cases should
be confirmed either by microscopy or using a rapid diagnostic test (RDTs) before any
treatment. Despite the crucial role of RDTs in improving malaria case management SSA, many
malaria cases are missed in pregnant women due to the power performance of recommended RDTs
which are unable to detect very low parasitaemia. Identifying lower density infections in
pregnant women by the use of highly-sensitive RDTs and clearing them with an effective ACT
could improve the outcome of the pregnancy in addition to IPTp-SP.
Phase:
Phase 3
Details
Lead Sponsor:
Institut de Recherche en Sciences de la Sante, Burkina Faso
Collaborator:
European and Developing Countries Clinical Trials Partnership (EDCTP)