Some individuals smoke with the perception that smoking helps control body weight. Smokers
gain an average of as much as 10 pounds in the months following smoking abstinence, with
heavier and more-dependent smokers gaining more weight. T The Mayo Clinic Nicotine Research
Program will randomize 100 nondiabetic, overweight or obese adult smokers to active
lorcaserin or placebo for 24 weeks; all of the subjects will receive open-label varenicline
for 12 weeks. The purpose of this study is to assess the efficacy of a 24-week course of
lorcaserin for decreasing weight gain after stopping smoking.