Adenosin to Rapidly Reverse Left Ventricle Impairment in Takotsubo Syndrome

• Status: Terminated
• Trial end date: 2018-10-01
• Target enrollment: 0
• Participant gender: All

Summary

The investigators will randomize patients admitted to hospital with Takotsubo diagnosis to systematic high-dose adenosine infusion for 3 minutes (in addition to standard of care) vs. standard of care. The primary aim of the study is to demonstrate that adenosine infusion is associated with a larger and more rapid recovery of left ventricle function.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University Hospital of Ferrara
• Treatments: Adenosine; Pharmaceutical Solutions

Criteria

Inclusion Criteria:

• 18 years old

• Evidence of typical anatomical pattern to the left ventriculography (total akinesia of the mid-apical segments with hypercontractility basal segments) associated with the presence of criteria for the diagnosis of Takotsubo syndrome (Table 1)

• signing of informed consent

Exclusion Criteria:

• allergy to adenosine

• known and documented diagnosis of asthma

• pre-existing ischemic heart disease

• presence of arrhythmic complication (AV block grade II type 2 and third degree)