Adenosine and A2A Receptors in Human Brown Adipose Tissue

• Status: Completed
• Trial end date: 2016-06-30
• Target enrollment: 0
• Participant gender: Male

Summary

This study investigates the significance of adenosine and A2A receptors in human brown adipose tissue (BAT) in vivo. Using positron emission tomography (PET), perfusion and the density of A2A receptors will be measured in supraclavicular BAT and other tissues in healthy men. The investigators hypothesize, that adenosine can activate BAT, and that adenosine A2A receptor density changes when BAT is activated by cold exposure.

Understanding the mechanisms of BAT activation and the role of endocannabinoids in humans is important and beneficial in fighting against the epidemic of obesity and diabetes.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Turku University Hospital
• Collaborator: University of Bonn
• Treatments: Adenosine

Criteria

Inclusion Criteria:

1. Male sex

2. BMI 20 - 28 kg/m2

3. Age: 18- 40 years

4. Normal OGTT

5. Healthy, no regular medication

Exclusion Criteria:

1. BMI < 20 kg/m2 or BMI > 28 kg/m2

2. Low or high blood pressure

3. Asthma or other obstructive lung disease

4. Sick sinus syndrome, prolonged QT-interval, or any heart disease

5. Any chronic disease that could affect the study outcome, including diabetes

6. Mental disorder or poor compliance

7. Eating disorder or excessive use of alcohol, tobacco smoking or drug use

8. Past dose of radiation

9. Any other condition that in the opinion of the investigator could create a hazard to the subject safety, endanger the study procedures or interfere with the interpretation of study results