Adequacy of Perioperative Cefazolin for Surgery Antibiotic Prophylaxis in Obese Patients
Status:
Withdrawn
Trial end date:
2018-10-01
Target enrollment:
Participant gender:
Summary
The population continues to increase in weight. Currently there are no guidelines in the
dosing of cefazolin for the obese population. Standard dosing of cefazolin 2 grams for
patients <120 kg and 3 grams for patients >120 kg is used as the dose for surgical
prophylaxis. This makes no provisions for weight based dosing. There has been some recent
data which states this might not be enough for the obese patients. The primary objective of
this study is to determine if weight based dosing (30 mg/kg) of cefazolin as surgical
prophylaxis for patients undergoing elective gastric bypass/laparoscopic Roux-en-y gastric
bypass provides appropriate serum concentrations for a larger percentage of time than the
current method of giving the standard 2 or 3 gram doses of cefazolin peri-operatively. The
concentration of cefazolin in tissue will also be measured to help assess this question.