Adipose Tissue Storage in the Rapid Remission of Hepatic and Cardiac Metabolic Dysfunction After Bariatric Surgery

• Status: Recruiting
• Trial end date: 2028-05-01
• Target enrollment: 0
• Participant gender: All

Summary

The present protocol aims to understand and establish whether there is a causal link between adipose tissue metabolic remodeling and Type 2 Diabetes (T2D) remission after bariatric surgery.

All participants will have a bariatric surgery, divided in 2 groups: with or without T2D.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Université de Sherbrooke
• Collaborators: Centre de recherche du Centre hospitalier universitaire de Sherbrooke; Institut universitaire de cardiologie et de pneumologie de Québec, University Laval
• Treatments: Niacin; Niacinamide; Nicotinic Acids

Criteria

Inclusion Criteria:

• Aged 18 to 65

• BMI 35 kg/m2

• Diagnosed T2D - according to Diabetes Canada diagnostics criteria.

• Diagnosed non-T2D - according to Diabetes Canada diagnostics criteria.

• Women with a negative serum pregnancy test.

Exclusion Criteria:

• Treatment with an oral contraceptive;

• Treatment with fibrate, thiazolidinedione, insulin, or beta-blocker, drugs that affect metabolism and cannot be stopped temporarily or which have long-lasting effects;

• Presence of overt cardiovascular disease, liver or renal failure or other uncontrolled medical conditions;

• Any other contraindication to surgery or to temporarily suspending current medications for diabetes, lipids or hypertension;

• Smoking or consumption of more than 2 alcoholic beverages per day;

• Any contraindication to MRI;

• A Diabetes Remission (DiaRem) score >8 (low probability of T2D remission);

• Having participated to a research study with exposure to radiation in the last two years before the start of the study;

• Pregnant or breastfeeding women;

• Patients weighing more than 200 kg to respect the weight and gantry limit of our MRI and PET/CT scanners.

• Being allergic to eggs