Adjunct Dexmedetomidine (Precedex®) Therapy Impact on Sedative and Analgesic Requirement

• Status: Withdrawn
• Trial end date: 2009-03-01
• Target enrollment: 0
• Participant gender: All

Summary

Assess impact of increasing dose of dexmedetomidine on total daily dose of fentanyl and propofol while maintaining sedation in a mechanically ventilated patient in a general medical intensive care unit.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Avera McKennan Hospital & University Health Center
• Treatments: Analgesics; Dexmedetomidine; Hypnotics and Sedatives

Criteria

Inclusion Criteria:

• surgical, medical, or trauma patients requiring sedation for mechanical ventilation

• age 18-80

• Anticipated ventilation time of > 24 hrs

• Reasonable chance of recovery

Exclusion Criteria:

• Severe COPD

• Chronic immunosuppression (equivalent to prednisone 7.5 mg daily or higher)

• Heart block

• Bradycardia

• Significant head injury

• Goal SAS score of 1-2

• Severe hepatic impairment

• Hypertriglyceridemia

• Allergy to dexmedetomidine, fentanyl, propofol or eggs