Adjuvant ChemoRadiotherapy Prior to Surgery in Stage IVa Oral Cancers

• Status: Completed
• Trial end date: 2019-03-15
• Target enrollment: 0
• Participant gender: All

Summary

Oral cancer is the single largest cancer in males in India. 90-95% cases of oral cancer are Squamous cell carcinomas and many of them present at late stages (T3 and above). Treatment of OSCC includes single modality surgery, radiotherapy, or combinations of these modalities with or without systemic therapy. For unresectable cases, radiotherapy and/or chemotherapy is the treatment modality. Efficacy of neoadjuvant chemoradiotherapy for resectable stage IV tumors (late stage) needs to be evaluated to assess its benefit before surgery.

• Phase: Early Phase 1
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Indrayani Hospital and Cancer Institute
• Collaborators: Grant Medical Foundation Ruby hall Clinic; Tata Capital Limited

Criteria

Inclusion Criteria:

1. Histologically confirmed stage IVa squamous cell carcinoma of the oral cavity.

2. Surgically resectable oral squamous carcinoma with invasion of mandible or maxilla.

3. Newly diagnosed or previously untreated squamous cell carcinoma of the oral cavity.

Exclusion Criteria:

1. Patients with distant metastases.

2. Patients with contraindication to radiotherapy.

3. Patients with vascular disorders or ischemic heart disease. -