Adjuvant Chemotherapy Plus Codonopsis Pilosula Nnannf /Placebo
Status:
Recruiting
Trial end date:
2024-12-30
Target enrollment:
Participant gender:
Summary
Pancreatic carcinoma patients got benefit from adjuvant therapy after radical surgery.
Gemcitabine combined with albumin-paclitaxel was recommended as the first-line regimen for
adjuvant chemotherapy by NCCN guidelines. The most common non-hematological adverse events
associated with gemcitabine combined with albumin-paclitaxel treatment were fatigue (54%),
followed by alopecia (50%), and grade 3 or higher adverse events were mainly
granulocytopenia, leukopenia, fatigue, and peripheral nerve damage. Cancer-related fatigue
(CRF) is the most common concomitant symptom in cancer patients, especially during
chemotherapy, which has a negative impact on patients' work, social relationships, emotions
and daily activities. Therefore, it is of great clinical significance to improve CRF in
cancer patients. From the perspective of traditional Chinese medicine, CRF patients will have
a series of syndromes such as low function of viscera, general weakness, and emaciation,
which last for more than 2 weeks and affect patients' physiology and psychology at the same
time. Codonopsis pilosula Nnannf can restore the postoperative immune ability of patients as
soon as possible after chemotherapy.