Adjuvant Chemotherapy in Clinical Local Advanced CRC Following Preoperational Therapies and pT0-3N0M0 Diagnosis
Status:
Recruiting
Trial end date:
2026-12-30
Target enrollment:
Participant gender:
Summary
Adjuvant chemotherapy was unnecessary in pathological stage Ⅱ colorectal cancer following
initial treatment of surgery without high risk factors of recurrences. The treatment efficacy
of adjuvant chemotherapy for pT1-3N0M0 colorectal cancer following preoperational
chemotherapy or chemoradiotherapy remains unclear. Part of clinical local advanced colorectal
cancer(cTxN1-2M0), which turn out to be pT0-3N0M0 after preoperational chemotherapy or
chemoradiotherapy, might not really need adjuvant chemotherapy due to the down-stage efficacy
of the preoperational treatments, or the misleading by lymph nodes false-positive imaging
diagnosis.