Administration of Acetazolamide to Prevent Remifentanil Induced Hyperalgesia
Status:
Completed
Trial end date:
2018-09-28
Target enrollment:
Participant gender:
Summary
Remifentanil is a potent opioid widely used during the administration of general anesthesia.
There is a lot of evidence that suggest that the used of remifentanil is associated with the
development of hyperalgesia (a reduction of nociceptive thresholds). However, the mechanism
of this hyperalgesia is not fully understood.
Recently, it was demonstrated that the disruption of the Cl- homeostasis could be involved.
Interestingly, this was prevented in a murine model with the administration of Acetazolamide,
a carbonic anhydrase inhibitor. In our clinical trial we will try to determine if the
preoperative administration of acetazolamide could prevent the hyperalgesia induced by
remifentanil in patients scheduled for thyroidectomy with general anesthesia.