Administration of Methylprednisolone for Prevention of Ovarian Hyper Stimulation Syndrome

• Status: Completed
• Trial end date: 2010-12-01
• Target enrollment: 0
• Participant gender: Female

Summary

This study is a prospective randomized clinical controlled trial to assess the efficacy of the Methylprednisolone for preventing ovarian hyper stimulation syndrome in in vitro fertilization (IVF) cycles.

• Phase: Phase 1/Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Royan Institute
• Treatments: Methylprednisolone; Methylprednisolone Acetate; Methylprednisolone Hemisuccinate; Prednisolone; Prednisolone acetate; Prednisolone hemisuccinate; Prednisolone phosphate

Criteria

Inclusion Criteria:

• Poly Cystic Ovarian Syndrome patients

• Indication for IVF/ICSI and Long Protocol ovarian stimulation

• Basal FSH≥10

• Normal BMI (20-25)

• physical health

Exclusion Criteria:

• Allergy to GnRH analogues, FSH and corticosteroids

• presence of heart failure, recent myocardial infarction

• Hypertension

• Diabetes mellitus

• epilepsy

• glaucoma

• hypothyroidism

• hepatic failure

• osteoporosis

• peptic ulceration

• renal impairment

• Using drugs that have interaction with corticosteroids such