Adoptive Immunotherapy, Aldesleukin, and Zoledronate in Treating Patients With Stage IV Kidney Cancer and Lung Metastases

• Status: Completed
• Trial end date: 2009-08-01
• Target enrollment: 0
• Participant gender: All

Summary

RATIONALE: Cellular adoptive immunotherapy uses a person's white blood cells that are treated in the laboratory to stimulate the immune system in different ways and stop tumor cells from growing. Aldesleukin may help the laboratory-treated white blood cells stay in the body longer. Drugs used in chemotherapy, such as zoledronic acid, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Giving cellular adoptive immunotherapy together with interleukin-2 and zoledronic acid may kill more tumor cells.

PURPOSE: This phase I/II trial is studying the side effects of giving cellular adoptive immunotherapy together with aldesleukin and zoledronic acid and to see how well it works in treating patients with stage IV kidney cancer and lung metastases.

• Phase: Phase 1/Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Tokyo Women's Medical University
• Treatments: Aldesleukin; Zoledronic Acid

Criteria

DISEASE CHARACTERISTICS:

• Histologically confirmed renal carcinoma

• Stage IV disease with lung metastases

• Bidimensionally measurable lung metastases by CT scan

• Meets 1 or more of the following criteria:

• No change in disease status or progressive disease after prior aldesleukin administration for 3 months or more

• Lung metastases after treatment with prior nephrectomy

• Patients with clear cell renal carcinoma must have undergone nephrectomy prior to study entry

• Patients with progression of metastatic lung cancer after nephrectomy also must have received interferon alfa for 3 months or more (prior to study entry)

PATIENT CHARACTERISTICS:

• ECOG performance status 0-1

• Life expectancy > 6 months

• Leukocyte count ≥ 3,000/mm³

• ANC ≥ 1,500/mm³

• Platelet count ≥ 100,000/mm³

• Serum bilirubin ≤ 1.5 mg/dL

• AST/ALT ≤ 2.5 times normal

• Serum creatinine ≤ 1.7 mg/dL

• LDH ≤ 1.5 times normal

• Not pregnant nor nursing

• Negative pregnancy test

• Fertile patients must use effective contraception

• No active infection with hepatitis virus or HIV

• No poorly controlled heart failure or arrhythmia

• No hypercalcemia that require medication

• No C-reactive protein with an infectious disease that requires medication

PRIOR CONCURRENT THERAPY:

• See Disease Characteristics

• At least 3 weeks since prior chemotherapy, radiation therapy, or biologic therapy

• No prior bone marrow transplantation or organ transplantation

• No concurrent steroid therapy

• No concurrent antidepressant therapy