Adrenal Functions in Autosomal Dominant Polycystic Kidney Disease

• Status: Completed
• Trial end date: 2007-09-01
• Target enrollment: 0
• Participant gender: All

Summary

We aimed to evaluate the hypothalamus-pituitary-adrenal axis in autosomal dominant polycystic kidney disease (ADPKD) patients. Twenty two ADPKD patients and 27 healthy subjects were enrolled.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Istanbul University
• Treatments: Cosyntropin; Epinephrine; Epinephryl borate; Racepinephrine

Criteria

Inclusion Criteria:

• Healthy subjects

• Diagnosis of autosomal dominant polycystic kidney disease

Exclusion Criteria:

• A glomerular filtration rate below 60 ml/min

• History of recent major surgery

• Systemic infections with fever

• Significant hirsutism (Ferriman Gallwey score≥8)

• Congenital adrenal hyperplasia

• Late onset congenital adrenal hyperplasia

• Systemic corticosteroid use (including previous use)

• Topical corticosteroid use

• Menstrual irregularity

• History of thromboembolism

• Uncontrolled diabetes or hypertension

• History of psychosis

• Pregnancy

• Lactation

• History of hypersensitivity to tetracosactin