Adrenal Insufficiency in Cirrhotics With Ascites. Effects of Hydrocortisone on Renal and Haemodynamic Function
Status:
Unknown status
Trial end date:
2009-05-01
Target enrollment:
Participant gender:
Summary
Relative adrenal insufficiency (RAI) is an well known condition in patients with septic
shock. Liver failure (including chronic liver failure)and sepsis are both characterized by
hyperdynamic circulatory failure (with low arterial pressure) and high levels of
pro-inflammatory cytokines.
Hydrocortisone has been shown to have a beneficial effect on clinical outcome. The aim of
this study is to evaluate the incidence of RAI in the different settings of ascites in
cirrhosis and the usefulness of hydrocortisone in this context.