Adrenal Responsiveness During the Perioperative Period in Children Undergoing Congenital Cardiac Surgery
Status:
Completed
Trial end date:
2013-06-01
Target enrollment:
Participant gender:
Summary
Our objective was to determine whether a standard 1mg/kg intraoperative dose of dexamethasone
results in similar drug levels for all patients and to characterize the relationship between
these drug levels and the innate stress response following infant Cardiopulmonary Bypass
(CPB). The investigators hypothesized that postoperative dexamethasone levels are highly
variable, and that the infant stress response is inversely related to the amount of
dexamethasone measured in the blood. To test this theory the investigators simultaneously
measured blood levels of dexamethasone and cortisol at critical time points during the
perioperative period for infants undergoing CPB for CHD surgery.