Adrenal Responsiveness During the Perioperative Period in Children Undergoing Congenital Cardiac Surgery

• Status: Completed
• Trial end date: 2013-06-01
• Target enrollment: 0
• Participant gender: All

Summary

Our objective was to determine whether a standard 1mg/kg intraoperative dose of dexamethasone results in similar drug levels for all patients and to characterize the relationship between these drug levels and the innate stress response following infant Cardiopulmonary Bypass (CPB). The investigators hypothesized that postoperative dexamethasone levels are highly variable, and that the infant stress response is inversely related to the amount of dexamethasone measured in the blood. To test this theory the investigators simultaneously measured blood levels of dexamethasone and cortisol at critical time points during the perioperative period for infants undergoing CPB for CHD surgery.

• Phase: Phase 1
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Mayo Clinic
• Treatments: Adrenocorticotropic Hormone; beta-Endorphin; Cosyntropin; Epinephrine; Epinephryl borate; Melanocyte-Stimulating Hormones; Racepinephrine

Criteria

Inclusion Criteria:

• less than 365 days of age

• Congenital cardiac surgery that requires cardiopulmonary bypass

Exclusion Criteria:

• Corticosteroids within 24 hours prior to enrollment

• Less than 36 weeks gestational age at time of surgery

• pre-operative mechanical circulatory support (ECMO)