Overview

Adult Growth Hormone Deficiency and Cardiovascular Risk

Status:
Terminated

Trial end date:
2011-05-01

Target enrollment:
0

Participant gender:
All

Summary

This protocol will assess the cardiovascular risk associated with growth hormone deficiency in adults. We will use multiple modalities to assess risk for heart attacks or strokes including blood work, ultrasound, MRI and endothelial cell biopsies in both patients who are growth hormone deficient and in patients with normal growth hormone secretion. We hypothesize that adults with growth hormone deficiency will have results suggestive of an increased risk for cardiovascular disease.

Phase:

N/A

Accepts Healthy Volunteers?

Details

Lead Sponsor:

Columbia University

Treatments:

Growth Hormone-Releasing Hormone
Hormones

Criteria

Inclusion Criteria:

- Adults 19 years or older who have undergone transsphenoidal surgery for a clinically
non-secreting pituitary adenoma

Exclusion Criteria:

- Currently taking growth hormone, radiation therapy in the past 5 years, changes in
dose of other pituitary hormone replacement therapy in past 3 months, taking
hydrocortisone (or its equivalent) at a dose of > 30 mg/day, pregnant or nursing women