Overview

Aerosol Particle Size and Breathing Pattern During Inhaled Furosemide

Status:
Unknown status
Trial end date:
2020-09-01
Target enrollment:
0
Participant gender:
All
Summary
The study hypothesises that the variability in relief of air hunger with inhaled furosemide that is reported in previous studies can be explained by the breathing pattern adopted during the inhalation and the droplet size in the aerosol, both of which would influence the site of deposition of the aerosol in the lungs
Phase:
Phase 1
Accepts Healthy Volunteers?
Accepts Healthy Volunteers
Details
Lead Sponsor:
Oxford Brookes University
Treatments:
Furosemide
Criteria
Inclusion Criteria:

- Healthy volunteers aged 18 and over

Exclusion Criteria:

- On any medication, including herbal medication (other than mild analgesics, vitamins
and mineral supplements or, for females, oral contraceptives), whether prescribed or
over-the-counter, in the two weeks prior to test sessions involving administration of
furosemide or saline.

- Female participants who are pregnant, lactating or planning pregnancy over the course
of trial

- A medical history of heart, kidney or liver disease/electrolyte disturbances/
immunosuppression/frequent fainting episodes/COPD/nasal polyps/Addison's/acute
porphyria/significant prostatic symptoms/acute gout attack/life expectancy <6months or
history of allergic reaction to furosemide and/or any of the other ingredients of
furosemide or amiloride, sulfonamides or sulphonamide derivatives, such as
sulfadiazine or co-trimoxazole

- Any other significant disease or disorder which, in the opinion of the Investigator,
may either put the participants at risk because of participation in the trial, or may
influence the result of the trial, or the participant's ability to participate in the
trial.

- Have participated in another research trial involving an investigational product in
the past 4 weeks.