Aerosolized Antibiotics and Respiratory Tract Infection in Patients on Mechanical Ventilation

• Status: Completed
• Trial end date: 2004-09-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study was to determine the effect of aerosolized antibiotics on respiratory infection in mechanically ventilated patients.We hypothesize that aerosolized antibiotics , which achieve high drug concentrations in the airway, would more effectively treat respiratory infection, decrease the need for systemic antibiotics and decrease antibiotic resistance.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Stony Brook University
• Collaborator: Nektar Therapeutics
• Treatments: Anti-Bacterial Agents; Antibiotics, Antitubercular; Gentamicins; Vancomycin

Criteria

Inclusion Criteria:

• be on mechanical ventilation greater than 3 days

• greater than or equal to 18 years of age survival greater than 14 days

• greater than 2 ccs of tracheal secretions/4 hours

Exclusion Criteria:

• allergy to drugs, pregnancy