Age-Related Effects of THC

• Status: Completed
• Trial end date: 2021-05-01
• Target enrollment: 0
• Participant gender: All

Summary

Increased accessibility to cannabis and its primary psychoactive constituent THC has raised public health concerns. One major concern surrounds the potential risks associated with acute THC intoxication and who might be most at risk. A second major concern is the need to develop sensitive measures that can detect THC intoxication after recent use and enable robust comparisons of intoxication to determine sources of risk. One potential source of risk is age, specifically during the period of adolescence.

• Phase: Early Phase 1
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: University of Chicago
• Treatments: Dronabinol

Criteria

Inclusion Criteria:

• 18-20 years old OR 30-40 years old

• Body Mass Index 19-26

• High school education, fluent in English

• Occasional cannabis users ( 0 times in past 30 days AND used cannabis no more than 20 times in lifetime)

Exclusion Criteria:

• History of daily cannabis use

• Past or present severe substance use disorder

• Current or past diagnosis with drug treatment for psychosis/bipolar/schizophrenia

• Cardiovascular illness, high blood pressure, abnormal electrocardiagram

• Current medications

• Pregnant or planning to become pregnant