Aggressive hydraTion in Patients With ST -Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention to prevenT Contrast-Induced Nephropathy

• Status: Unknown status
• Trial end date: 2017-07-01
• Target enrollment: 0
• Participant gender: All

Summary

To compare the efficacy of 2 different hydration strategies, hydration according to clinical guideline and adequate hydration, on contrast-induced nephropathy in patients with STEMI undergoing primary PCI to investigate the possible beneficial role of periprocedural adequate hydration.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Guangdong General Hospital; Guangdong Provincial People's Hospital
• Collaborators: Chinese PLA General Hospital; Fudan University; Peking University First Hospital

Criteria

Inclusion Criteria:

• all consecutive patients with STEMI, age at least 18 years, who were candidates for primary PCI were considered for enrollment.

Exclusion Criteria:

• contrast medium administration within the previous 14 days or follow 72 hours,

• end-stage renal failure or renal transplantation, and refuse PCI or dead during the procedure,

• heart failure of cardiac shock or New York Heart Association class IV,

• recent acute kidney injury defined as an absolute increase of 0.5 mg/dl in serum creatinine over baseline in the past 24h

• ,the presence of lactation, pregnancy,

• malignant tumour or life expectancy less than 1 year,

• allergy to contrast, peri-procedural receipt of metformin non-steroidalanti-inflammatory drugs in the past 48h and during the study period,

• planned renal catheterization or heart valvular surgery。