Airborne Ultrafine and Fine Particulate Matter: A Cause for Endothelial Dysfunction in Man?

• Status: Completed
• Trial end date: 2009-05-01
• Target enrollment: 0
• Participant gender: Male

Summary

The purpose of this study is to examine biological pathways of altered blood vessel function resulting from breathing airborne particulate. Blood artery function in healthy men will be measured after particulate exposure either on placebo or on an asthma medication that stops production of an inflammatory biological agent. Lung and blood profiles will be obtained before and after exposure to exhaust fumes. We believe that the inflammatory agent produced by the lungs from breathing these particles causes abnormal artery function.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Marywood University
• Treatments: Montelukast

Criteria

Inclusion Criteria:

• Healthy male subjects

• between 18 and 30 years of age

• participant in endurance sport

Exclusion Criteria:

• history of blood clotting

• history of coagulation problems

• History of spontaneous pneumothorax