Airborne Ultrafine and Fine Particulate Matter: A Cause for Endothelial Dysfunction in Man?
Status:
Completed
Trial end date:
2009-05-01
Target enrollment:
Participant gender:
Summary
The purpose of this study is to examine biological pathways of altered blood vessel function
resulting from breathing airborne particulate. Blood artery function in healthy men will be
measured after particulate exposure either on placebo or on an asthma medication that stops
production of an inflammatory biological agent. Lung and blood profiles will be obtained
before and after exposure to exhaust fumes. We believe that the inflammatory agent produced
by the lungs from breathing these particles causes abnormal artery function.