Airway Dimension Study in Children Undergoing MRI Sedated With Propofol and Dexmedetomidine

• Status: Terminated
• Trial end date: 2019-04-30
• Target enrollment: 0
• Participant gender: All

Summary

Sedation is required in infants and children to successfully complete MRI while maintaining respiratory and hemodynamic stability. Limited access to the patient may pose a safety risk during MRI examination. Therefore, appropriate drugs need to be selected, administered, and titrated to achieve these objectives. Propofol is commonly used for sedation in children in the MRI setting because of its predictability, rapid onset, and offset of action. Dexmedetomidine has sedative and analgesic properties without affecting cardiovascular and respiratory stability. The rationale of this research is to assess the effect of these drugs on the upper airway and validate their use in children with upper airway disorders.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Milton S. Hershey Medical Center
• Treatments: Dexmedetomidine; Propofol

Criteria

Inclusion Criteria:

• Children undergoing MRI brain

• Age 2 - 5 yrs

• ASA I - II

Exclusion Criteria:

• OSA

• Pathology of upper airway

• Craniofacial anomalies

• Gastroesophageal reflux

• Increased intracranial pressure

• Body weight of 20% more than ideal

• Contraindication to the use of either drug

• Failure to maintain a patent airway during the study