Airway Inflammation in Children With Allergic Rhinitis and Intervention

• Status: Completed
• Trial end date: 2015-10-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to determine whether treating upper airway with intranasal corticosteroids in children with allergic rhinitis and no asthma may bring favors in reducing lower airway inflammation and improving small airway function.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Guangzhou Institute of Respiratory Disease
• Treatments: Budesonide

Criteria

Inclusion Criteria:

• clinical diagnosis of allergic rhinitis without asthma

• sensitized to more than 1 common aeroaller¬gens

• FeNO >20ppb and/or induced sputum Eosinophil>2.5%

Exclusion Criteria:

• Respiratory infection 2 weeks prior to initial visit

• children with nasal polyposis

• History of immunotherapy

• unable to complete the test or had limited understanding

• Use of systemic corticosteroids 4 weeks prior to initial visit

• nasal and inhaled corticosteroids 2 weeks prior to initial visit

• leukotriene receptor antagonists 2 weeks prior to initial visit

• Use of antihistamines 7 days prior to initial visit