Airway Inflammation in Congenital Diaphragmatic Hernia Patients
Status:
Completed
Trial end date:
2013-10-01
Target enrollment:
Participant gender:
Summary
We propose to examine Congenital Diaphragmatic Hernia (CDH) patients for evidence of airway
inflammation as a first step to characterize the reported bronchodilator responsiveness.
Airway biopsy studies are invasive and thus we propose to perform induced sputum studies to
document the amount and type of inflammation present. Another ancillary non-invasive measure
of airway inflammation that we will use is exhaled nitric oxide (NO). The primary objective
of this study is to determine if CDH patients have any evidence of airway inflammation. The
hypothesis of this study is that children with CDH do not have evidence of airway
inflammation associated with bronchodilator responsiveness. Based on this information,
treatment for CDH patients will hopefully be more accurate and appropriate for their specific
needs.