Airway Response to Repeat Allergen Challenge and the Effect of Ibuprofen in Mild Atopic Asthma

• Status: Completed
• Trial end date: 2015-04-01
• Target enrollment: 0
• Participant gender: All

Summary

The study will assess airway responses in mild atopic asthmatics undergoing repeat allergen challenge testing and will investigate whether ibuprofen changes the response.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of Saskatchewan
• Treatments: Ibuprofen

Criteria

Inclusion Criteria:

• diagnosis of mild asthma, currently well controlled requiring only a bronchodilator (e.g. salbutamol) as needed and infrequently

• has allergies that trigger asthma

• responds to methacholine challenge at 16mg/ml or less

• has FEV1 > 69.5% predicted

Exclusion Criteria:

• respiratory illness within 4 weeks

• other medical condition assessed by the principal investigator that would put the participant at risk or influence the integrity of the data

• pregnant or lactating females

• hypersensitivity to ibuprofen