Airway and Pulmonary Vascular Endothelial Function in Healthy Smokers: Effect of Inhaled Glucocorticosteroid Treatment
Status:
Completed
Trial end date:
2015-12-01
Target enrollment:
Participant gender:
Summary
The purposes of the present proposal are to 1) compare inhaled albuterol-induced changes in
airway blood flow (Qaw), and in CO and Ppas in healthy current smokers and lifetime
non-smokers as an index of endothelial function in the airway and pulmonary circulations, 2)
compare the results between smokers and non-smokers, and 3) determine the effect of a 4-week
treatment with an ICS on albuterol responsiveness of Qaw and the echocardiographic
parameters. With this protocol the Investigators will test the hypotheses that a) there is a
correlation between airway and pulmonary vascular endothelial function within the current
smoker and non-smoker groups, and b) ICS treatment improves airway and pulmonary vascular
endothelial function in the current smoker group.