Albumin 4 gr/L vs 8 gr/L in the Prevention of Post-Paracentesis Circulatory Dysfunction

• Status: Unknown status
• Trial end date: 2008-12-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to determine whether the infusion of albumin 4 gr per liter of ascites removed is as effective as the infusion of albumin 8 gr per liter of ascites removed in the prevention of post-paracentesis circulatory dysfunction

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of Turin, Italy

Criteria

Inclusion Criteria:

• Cirrhosis and ascites submitted to paracentesis > 5 liters

• Age: 18-75 years

• Informed written consent

Exclusion Criteria:

• Multinodular HCC (> 3 nodules)

• Portal vein thrombosis

• Ongoing bacterial infection

• Ongoing or recent (less than one week) bleeding

• Cardio-pulmonary failure

• Hepatorenal syndrome type 1

• Severe coagulopathy: platelets < 30.000/mm3 and/or PT < 30%

• Ongoing treatment with vasoactive drugs