Albuterol and Immune Cell Composition

• Status: Withdrawn
• Trial end date: 2021-06-20
• Target enrollment: 0
• Participant gender: All

Summary

The aim of this pilot study is to determine the effects of albuterol on the composition of immune cells in the bloodstream for possible future use in patients with neuroblastoma.

• Phase: Early Phase 1
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: University of Arizona
• Treatments: Albuterol

Criteria

Inclusion Criteria:

• Any gender

• 21-44 years of age

Exclusion Criteria:

• Subjects must not: be younger than 21 or older than 44 years of age

• Indicate a condition on the ACSM-AHA preexercise screening questionnaire indicating that physician approval is required prior to exercise

• current user of tobacco products or have quit within the previous 6-months

• body mass index of >30 kg/m2, or waist girth of >102cm for men and >88cm for women

• use over-the-counter medication known to affect the immune system (i.e. regular use of ibuprofen/aspirin, anti-histamines or beta-blockers)

• have chronic/debilitating arthritis

• have been bedridden in the past three months

• have common illness (i.e. colds) within the past 6-weeks

• have HIV

• have hepatitis

• have had a stroke

• have major affective disorder

• have any autoimmune disease

• have central or peripheral nervous disorders

• have blood vessel disease

• have cardiovascular disease (CVD)

• use of any prescription medication

• pregnancy or are breast-feeding

• asthma, emphysema, bronchitis, kidney disease; pheochromocytoma; diabetes; overactive thyroid

• history of severe anaphylactic reaction to an allergen

• or are scheduled to have surgery

• Individuals who pass the exclusion criteria detailed above but present with more than one of the following CVD risk factors will also be excluded from the study: family history of myocardial infarction, coronary revascularization, or sudden death before 55 years of age in father or other male first-degree relative or before 65 years of age in mother or other female first-degree relative; hypertension (systolic blood pressure of >140 mmHg or diastolic blood pressure >90 mmHg); dyslipidemia (total serum cholesterol of >200 mg/dl); pre-diabetes (fasting blood glucose of >100mg/dl but <126 mg/dl).