Aldosterone Blockade in Chronic Kidney Disease: Influence on Arterial Stiffness and Kidney Function
Status:
Terminated
Trial end date:
2012-02-01
Target enrollment:
Participant gender:
Summary
Patients with Chronic Kidney Disease (CKD) have a poor prognosis primarily due to
cardiovascular disease. The cardiovascular risk can be assessed by measurements of arterial
stiffness. A decrease in stiffness has been shown to decrease the risk of cardiovascular
disease as well as death. Most of the CKD population also have hypertension and the control
of blood pressure is one of the corner stones in inhibition of disease progression. Using
drugs that specifically block the renin-angiotensin-system for blood pressure control has
been shown to have a beneficial impact on inhibition of progression beyond that of the
achieved blood pressure control. It has been reported that inhibition of the hormone
aldosterone has a positive effect on survival in patients with heart failure, hypertension
and diabetic as well as on-diabetic nephropathy.
This study undertakes the investigation of the influence on arterial stiffness of adding an
aldosterone receptor inhibitor to the medication CKD patients are already taking. Besides the
primary end point which is Pulse wave velocity (PWV), arterial stiffness is also quantified
thorough ambulatory blood pressure measurements.