Alendronate Compared to Metformin in Chronic Periodontitis

• Status: Completed
• Trial end date: 2015-03-01
• Target enrollment: 0
• Participant gender: All

Summary

This is a 9 month randomised controlled clinical comparing the clinical efficacy of 1%metformin and 1%alendronate in chronic periodontitis subjects.

• Phase: Phase 2/Phase 3
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Government Dental College and Research Institute, Bangalore
• Treatments: Alendronate; Metformin

Criteria

Inclusion Criteria:

• All the subjects were systemically healthy

• subjects with sites having CAL ≥ 3 mm, PPD ≥ 5 mm,

• vertical bone loss ≥ 3 mm on intraoral periapical radiographs (IOPA) and

• subjects with no history of periodontal intervention in the last 6 months.

Exclusion Criteria:

• patients with systemic diseases like cardiovascular disease

• diabetes or HIV infection or on medications like corticosteroids which may impede the healing in periodontal tissues.

• pregnant/lactating females

• tobacco users

• alcoholics

• patients with unsatisfactory oral hygiene (plaque index greater than 1.5)

• teeth having gingival recession, caries involving pulp, intrabony defect present interproximally, grade 2/3 mobility

• Furthermore, patients allergic to Metformin and alendronate or those taking Metformin and alendronate systemically were excluded.