Alfentanil and the Elimination of Sympathetic Responses to Tracheal Intubation During Rapid Sequence Induction of Anesthesia: A Probability-based Approach

• Status: Completed
• Trial end date: 2011-10-01
• Target enrollment: 0
• Participant gender: All

Summary

Induction of anesthesia:

After 3 minutes pre-oxygenation with 100% oxygen, a blinded dose alfentanil (0,10,20,30,40,50 or 60 µg/kg, followed by thiopental 4 mg/kg and rocuronium 0.6 mg/kg will be administered over 15 sec. Laryngoscopy will be performed 40 s. after injection of rocuronium, with the goal being to have the endotracheal tube passed through the patients vocal cords and the cuff inflated within the following 15 s . The investigator performing the tracheal intubation is blinded to the dose of alfentanil administered.

Blood samples:

As part of the study efficacy, blood samples, will be collected prior to induction and 30 s., 1 min. 3 min. and 5 min postintubation to determine blood concentrations of alfentanil and catecholamines.

• Phase: Phase 4
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Oslo University Hospital
• Collaborator: University Hospital, Aker
• Treatments: Alfentanil

Criteria

Inclusion Criteria:

• ASA I and II patients and admitted for elective surgery.

• Aged 18-55 years

• Written informed consent

Exclusion Criteria:

• Body Mass Index (BMI) > 28 Kg/m²

• Patients with known allergy to study drug

• Patients with known porphyria

• Neuromuscular disease or undergoing treatment with drugs known to interfere with neuromuscular transmission.

• Mallampati class > 2airway anatomy, or anticipated difficulty with mask ventilation or tracheal intubation.

• Neuromuscular disease

• Pulmonary disease

• Cardiovascular disease.