Alkaline Diet for Insulin Sensitivity

• Status: Completed
• Trial end date: 2016-12-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to test the effect of increasing the body pH acutely with an alkaline medication (sodium bicarbonate, NaHCO3, sodibic) on glucose metabolism post meal in non diabetic subjects with normal renal function.

The investigators aim to determine whether there is an acute reduction in venous blood pH following a typical Western-style (high acid load) breakfast in healthy men and women, and whether this effect is attenuated by the concurrent administration of an alkaline medication. The effect on glucose metabolism, hunger/satiety and arterial stiffness post meal will be assessed.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Garvan Institute of Medical Research
• Treatments: Insulin

Criteria

Inclusion Criteria:

• Age range: 22-65

• Disease status: Healthy.

• Laboratory parameters: Fasting plasma glucose <7 mmol/L, HbA1c <6.5% (48 mmol/mol).

• Willingness to give written informed consent and willingness to participate and comply with the study.

Exclusion Criteria:

• Individuals with a personal history of diabetes, hypertension, cardiovascular disease, kidney disease, respiratory disease or inflammatory disease.

• Individuals treated with medications known to affect insulin sensitivity.

• Individuals with fasting plasma glucose ≥7 mmol/L, HbA1c ≥6.5% (48 mmol/mol).

• Individuals with an unstable body weight in the past 3 months (+/- 2 kg or more).

• Individuals with a history of a psychological illness or condition that may interfere with the participant's ability to understand the requirements of the study.

• Individuals who smoke.

• Individuals who consume more than 40 g of alcohol daily.