Overview

Allogeneic Stem Cell Transplantation (ALLOSCT) in Recessive Dystrophic Epidermolysis Bullosa (RDEB)

Status:
Terminated
Trial end date:
2015-09-01
Target enrollment:
Participant gender:
Summary
Reduced Intensity Conditioning (RIC) and Allogeneic Stem Cell Transplantation (AlloSCT) from family-related donors and unrelated cord blood (UCB) donors will be safe and well tolerated in selected patients with RDEB. To determine the event-free survival (EFS) and overall survival (OS) following RIC consisting of busulfan/fludarabine/alemtuzumab (BFA) and AlloSCT in selected patients with RDEB.
Phase:
Early Phase 1
Details
Lead Sponsor:
Columbia University
Treatments:
Alemtuzumab
Busulfan
Fludarabine
Lorazepam
Tacrolimus