Alpha-blocker Plus Diuretic Combination Therapy as Second-line Treatment for Nocturia in Men

• Status: Completed
• Trial end date: 2008-06-01
• Target enrollment: 0
• Participant gender: Male

Summary

The aim of the present study was to determine whether the combined administration of a diuretic agent, hydrochlorothiazide, at night would improve the frequency of nocturia unresponsive to alpha-blocker monotherapy in men with LUTS.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Seoul National University Hospital
• Treatments: Adrenergic alpha-Antagonists; Diuretics; Hydrochlorothiazide; Terazosin

Criteria

Inclusion Criteria:

• no response or < 25% reduction in subjective nocturia by the IPSS question 7 after 4-weeks of treatment with terazosin

• no response or < 25% reduction in objective nocturia by the FVC after 4-weeks of treatment with terazosin

• nocturia on average two times or more per night (according to the FVC) after 4-weeks of terazosin therapy

Exclusion Criteria:

• use of medications for the control of bladder symptoms

• use of sedatives or tranquillisers for treating sleep disturbances

• bladder tumours

• bladder stones

• urethral strictures

• neurogenic bladder dysfunction

• restricted mobility

• working primarily at night

• a documented history or clinical symptoms of prostatitis, prostate cancer, or prostatic intraepithelial neoplasia on biopsy

• serum PSA levels of >20 ng/mL

• a history of prostate surgery or radiotherapy, acute urinary retention or an indwelling catheter

• evidence of acute urinary infection (pyuria and bacteriuria)on urine analysis