Alterations of Blood Clotting With the Use of Sequential Compression Devices on the Lower Limbs

• Status: Terminated
• Trial end date: 2010-11-01
• Target enrollment: 0
• Participant gender: All

Summary

This study aims to assess possible alteration in coagulation (blood clotting) following treatment with sequential compression devices (SCD) plus low-molecular weight heparin (LMWH) as opposed to LMWH alone.

The investigators will examine coagulation in the early postoperative period of patients undergoing major abdominal surgery during their stay in our Intensive Care Unit.

In addition to common laboratory tests, the investigators will examine coagulation using TEG®, a device which allows a semi-quantitative examination of all phases of coagulation.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of Parma
• Treatments: Anticoagulants; Calcium heparin; Dalteparin; Heparin; Heparin, Low-Molecular-Weight; Tinzaparin

Criteria

Inclusion Criteria:

• Elective major abdominal surgery for neoplasm

• Planned admission to postsurgical ICU due to the patient's meeting one or more of the following:

• ASA Physical Status Class 4

• Surgery of modified Johns-Hopkins class ≥IV

• ASA 3 with modified Johns-Hopkins class 3 surgery

• Expected duration of surgery ≥8 h

Exclusion Criteria:

• History of coagulation abnormalities, either congenital or acquired

• Ongoing treatment with anticoagulants/antiplatelet agents other than LMWH or hormones

• Massive edema of the legs

• Severe peripheral arteriopathy or neuropathy

• Malformations or recent surgery/trauma to the lower extremities