Altering Activation Patterns Post-stroke

• Status: Active, not recruiting
• Trial end date: 2022-10-01
• Target enrollment: 0
• Participant gender: All

Summary

This study evaluates a new rehabilitation approach for stroke survivors in the chronic phase of recovery in which the combination of drug therapy (cyproheptadine) and active movement practice (AMP) is used to encourage increased voluntary muscle control and strength.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Rehabilitation Institute of Chicago; Shirley Ryan AbilityLab
• Collaborators: Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD); National Institutes of Health (NIH)
• Treatments: Cyproheptadine; Polystyrene sulfonic acid

Criteria

Inclusion Criteria:

• Chronic, severe hand hemiparesis resulting from a single stroke (Chedoke- McMaster Stroke Assessment: Stage of Hand 2 or 3)

• Single stroke occurring at least 6 months prior to enrollment

• Spasticity

• Capacity to provide informed consent

Exclusion Criteria:

• Excessive pain in paretic upper limb

• Hemispatial neglect (as assessed by the Behavioral Inattention Test)

• Apraxia (as assessed by the FABERS battery)

• Botulinum toxin injection in the upper extremity within the past 6 months

• Introduction of new anti-spasticity medication within the past 6 months

• Orthopaedic impairments

• History of seizure disorder

• Other major health impairment