Alternate Chemotherapy Regimens for the Clearance of W.Bancrofti Infection

• Status: Completed
• Trial end date: 2013-08-01
• Target enrollment: 0
• Participant gender: All

Summary

Diethylcarbamazine (DEC) essentially a micro-filaricidal drug is given for 12 days as standard treatment for the clearance of W. bancrofti infection. It takes about one year for the individuals to completely clear the microfilaria from the blood. It takes another two to four years to clear the antigen. The aim of the present study is to shorten the time taken for clearing the Mf and antigen from the blood either by co-administration or sequential administration of a macrofilaricidal drug, Albendazole or doxycycline. This study is a randomized, double blind, controlled clinical trial to study the efficacy of these drug combinations in complete clearance the Mf and antigen from the blood in shorter span of 180 days and 365 days respectively.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Indian Council of Medical Research
• Treatments: Albendazole; Diethylcarbamazine; Doxycycline

Criteria

Inclusion Criteria:

• Residing in or around Pondicherry and adjoining Tamilnadu areas

• Night blood microfilaria counts > 10 mf/ml by membrane filtration

• No history of treatment for filarial infection for the last two years at least

• Willing for home visits by the staff of the center

• Willing to give written informed consent

Exclusion Criteria:

• Body weight less than 30 kg

• Hepatic or renal disease as evidenced by clinical or biochemical abnormalities. - concurrent illness like hypertension, diabetes mellitus, cardiac conditions and epilepsy requiring chronic medication

• Psychiatric illness

• Patients under tetracycline or doxycycline therapy

• History of de-worming by albendazole or other anti-helminthic during last one year

• Pregnancy or lactation