Alternative Antibiotic Regime in the Treatment of GAgP

• Status: Completed
• Trial end date: 2014-07-01
• Target enrollment: 0
• Participant gender: All

Summary

The objective of this randomized clinical study was to evaluate the effect of systemic administration of moxifloxacin compared to amoxicillin plus metronidazole combined with non-surgical treatment in patients with generalized aggressive periodontitis (GAgP) in 6-month follow-up.

A total of 40 systemically healthy patients with GAgP will evaluate in this randomized clinical trial. Periodontal parameters (plaque index, gingival index, probing depth, bleeding on probing, clinical attachment level) will be recorded at baseline, 1st, 3rd and 6th month. Patients will receive either 400 mg moxifloxacin per os once daily or 500 mg metronidazole and 500 mg amoxicillin per os three times daily for 7 days consecutively.

• Phase: Phase 4
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Kocaeli University
• Treatments: Amoxicillin; Fluoroquinolones; Metronidazole; Moxifloxacin; Norgestimate, ethinyl estradiol drug combination

Criteria

Inclusion Criteria:

• The periodontal diagnosis of subjects with GAgP was established on the basis of clinical and radiographic criteria defined by the 1999 International World Workshop for a Classification of Periodontal Diseases and Conditions.

• Patients were included if they were between 18 and 35 years of age and otherwise healthy.

Exclusion Criteria:

• if the patients had any known systemic diseases or conditions that can/could influence the periodontal status (cancer, cardiovascular and respiratory diseases)

• history of hepatitis or HIV infection,

• immunosuppressive chemotherapy

• current pregnancy, planning a pregnancy or lactation

• requirement for antibiotic prophylaxis

• oral diseases other than GAgP, ongoing orthodontic therapy

• a history of antibiotic therapy or periodontal treatment within the preceding six months.

• Subjects were excluded if they had known allergies to quinolones or penicillin or metronidazole

• Not willing to participate to the study.

• Not accept to sign written informed consent