Alternative Paracetamol Treatments for the Neonate With a hsPDA
Status:
Not yet recruiting
Trial end date:
2022-01-01
Target enrollment:
Participant gender:
Summary
Early targeted treatment of a hemodynamically significant patent ductus arteriosus (hsPDA)
during the first week of life in preterm neonates is often recommended. Our standard first
line therapeutic approach is enteral acetaminophen. However many extremely low birth weight
infants may be on limited or no feeds when PDA closure is determined to be indicated, thus
restricting the use of enteral acetaminophen. Several studies have suggested that intravenous
acetaminophen is less effective than enteral. Thus, in this study, we propose to compare two
alternative modes of administration when enteral acetaminophen is not an option.