Alternative Sedation During Bronchoscopy

• Status: Completed
• Trial end date: 2012-05-01
• Target enrollment: 0
• Participant gender: All

Summary

This protocol hopes to determine whether the use of dexmedetomidine-ketamine can reduce the use of standard of care fentanyl-midazolam sedation during bronchoscopy. This may result in less respiratory depression while providing better compliance with the procedure.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of Pennsylvania
• Collaborators: Hospira, Inc.; Hospira, now a wholly owned subsidiary of Pfizer
• Treatments: Dexmedetomidine; Diphenhydramine; Fentanyl; Ketamine; Midazolam; Promethazine

Criteria

Inclusion Criteria:

• Adults over the age of 18 scheduled for elective flexible bronchoscopy in the endoscopy suite or OR of HUP

Exclusion Criteria:

• History of inability to complete bronchoscopy attributable to inadequate sedation

• Requiring more than 2 LPM supplemental oxygen to maintain SaO2 > 90%

• History of allergy to study medications

• Pregnancy

• A history of psychosis

• Any condition deemed likely by the pulmonologist or anesthesiologist to pose a significant risk due to elevation of blood pressure, including cerebral/aortic aneurysm, and or ischemic cardiovascular disease

• Bradydysrhythmia deemed significant by the anesthesiologist or pulmonologist

• A diagnosis of significant renal or hepatic impairment