Alveolar Management Following Teeth Extraction

• Status: Recruiting
• Trial end date: 2022-12-01
• Target enrollment: 0
• Participant gender: All

Summary

Investigation of the volume stability of the alveolar ridge, the bone structure and soft tissue appearance at a delayed dental implantation using two bone substitute materials (1. Human-Spongiosa, gefriergetrocknet, CHB; 2. collacone®)

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University Medicine Greifswald
• Collaborator: Botiss Medical AG

Criteria

Inclusion Criteria:

• Signed informed consent

• Indication for tooth extraction resulting in a edentulous gap

• Male and female patients with an age range 20-60 years

• Caucasian

• For female patients: a negative pregnancy test

• Normotonic blood pressure (according to the WHO definition):

• Men: 110/70 - 140/90 mm Hg

• Women: 100/60- 140/90mm Hg

Exclusion Criteria:

• Parallel implantation of another implant

• Parallel planned prosthetic restoration of the adjacent teeth

• Smoker (less than 5 years non-smoker)

• Nursing women

• Participation in another clinical trial which dates back to less than 3 months before inclusion in this clinical trial

• Intake of bisphosphonates

• Radiation therapy (medical history or current)

• Known Diabetes mellitus

• Inflammatory processes in the mouth (PSI> 2)

• Presence of autoimmune diseases (Rheumatoid arthritis, Sjögren's syndrome, Systemic lupus erythematosus)

• Presence of blood coagulation disorders (Haemophilia A/B), or the intake of anticoagulants (Warfarin, new oral anticoagulants, aspirin> 100 mg)

• Osteogenesis imperfecta

• Osteoporosis

• Leukemia

• Agranulocytosis

• Immunocompromised patients

• Acute phase and rehabilitation phase of myocardial infarction

• Oncogenes diseases

• Patients undergoing chemotherapy

• Sepsis

• Acute and chronic infections: sinusitis, rhinitis, pharyngitis and Otitis media

• Wound healing disorders

• Seizures

• Gingival hyperplasia

• Alcohol abuse

• Drug abuse

• Infectious diseases (HIV, Hepatitis B and C)