Alveolar Ridge Augmentation With Curcumin Combined With Xenograft

• Status: Not yet recruiting
• Trial end date: 2025-03-01
• Target enrollment: 0
• Participant gender: All

Summary

A study was performed to investigate the effect of curcumin on the osteogenic differentiation of human periodontal ligament stem cells (hPDLSCs) and its underlying potential mechanism. The Results was that Curcumin at an appropriate concentration had no cytotoxicity and could promote osteogenic differentiation of the hPDLSCs

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Ain Shams University
• Treatments: Curcumin

Criteria

Inclusion Criteria:

• Male and female with age range 25-45 years.

• Patient with enough alveolar ridge height, suffering from missing single or multiple maxillary anterior and /or premolar with insufficient alveolar ridge buccolingual (BL) width that interfere with conventional straight forward implant placement. The minimum BL width included in the study will be 4-5 mm to facilitate ridge splitting and expansion.

• Systemically free from any diseases as evidenced by Burket's oral medicine health history questionnaire.

• Patient available during follow up periods.

Exclusion Criteria:

• Smokers.

• Pregnant and breast feeding females.

• Patient unwilling to comply to oral hygienic instructions.

• Patients under any medication or medical condition that affect the bone quality.

• Vulnerable groups. (e.g decisions impaired individual).