Alzheimer's Disease: Therapeutic Potential of Estrogen

• Status: Completed
• Trial end date: 2007-12-01
• Target enrollment: 0
• Participant gender: Female

Summary

This is a 15-month study to determine the effectiveness of hormone replacement therapy in improving memory and the ability to live independently in postmenopausal women with Alzheimer's disease.

• Phase: Phase 2/Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of Wisconsin, Madison
• Collaborator: National Institute on Aging (NIA)
• Treatments: Estradiol; Estradiol 17 beta-cypionate; Estradiol 3-benzoate; Estradiol valerate; Estrogens; Medroxyprogesterone; Medroxyprogesterone Acetate; Polyestradiol phosphate; Progesterone

Criteria

Inclusion Criteria:

• Postmenopausal women with Alzheimer's disease and without other dementias (diagnosed by study staff or from an outside clinic)

• Mini Mental State Examination score greater than 15/30

Exclusion Criteria:

• History of cancer of reproductive tissues

• History of deep vein thrombosis or blot clots

• Diabetes

• Heart disease or stroke

• Liver problems including hepatitis

• Severe vision or hearing problems

• Tobacco use

• Lack of an adequate caregiver

• inability to perform psychometric testing