Amantadine for Treatment of Symptoms of the Post-traumatic Confusional State
Status:
Completed
Trial end date:
2019-03-01
Target enrollment:
Participant gender:
Summary
Patients with traumatic brain injury often experience a period of acute confusion that may
include agitation as they recover from their injuries. While this confusion generally
resolves with time, patients may pose increased risk of injury to themselves or others during
this period. Their behavior may also increase stress for family members and interfere with
their ability to benefit from rehabilitation therapies. A number of different medications
have been used to treat confusion to decrease agitation, decrease risk of injury, and improve
participation in rehabilitation therapies. To this point, there has not been a research or
scientific basis for knowing which medication is the best for a specific patient. The overall
goal of this study is to conduct a scientific investigation to help determine which
medication works best to treat confusion.
Study hypothesis: Amantadine will reduce the severity and number of symptoms of acute
confusion after traumatic brain injury.